Thermo Scientific microPHAZIR 1624 RX Portable Spectrometer

The Thermo Scientific microPHAZIR 1624 RX Portable Spectrometer is a handheld Near-Infrared (NIR) analyzer engineered for rapid pharmaceutical raw material identification, quality assurance, and non-destructive chemical verification directly in warehouses, laboratories, and production environments. Designed for portable field operation, this compact spectrometer enables manufacturers to perform real-time analysis without sending samples to a centralized laboratory.

The system combines portability, regulatory compliance, and fast measurement performance into a rugged handheld platform suitable for pharmaceutical manufacturing, biotechnology facilities, nutraceutical production, chemical inspection, and Process Analytical Technology (PAT) applications.

Introduction to the Thermo Scientific microPHAZIR RX Analyzer

Portable spectroscopy has become essential for pharmaceutical manufacturers that require immediate verification of incoming raw materials while maintaining strict compliance standards. The microPHAZIR RX analyzer brings laboratory-grade NIR technology directly to the point of inspection.

Unlike traditional benchtop spectrometers, this device allows operators to perform non-destructive analysis through glass containers and plastic liners, reducing contamination risk and improving operational efficiency. The analyzer is specifically optimized for pharmaceutical raw material identification (RMID) and counterfeit detection applications.

The instrument integrates advanced Near-Infrared spectroscopy with intuitive software, rapid measurement capabilities, and portable ergonomics.

Key Features of Thermo Scientific microPHAZIR 1624 RX

Handheld Portable Design

The lightweight ergonomic design enables one-handed operation in warehouses, production lines, and receiving areas. The analyzer weighs approximately 1.25 kg, making it suitable for continuous field use.

Rapid Non-Destructive Analysis

The system performs chemical identification within seconds using Near-Infrared spectroscopy without damaging samples or requiring sample preparation.

Pharmaceutical Compliance Support

The analyzer supports pharmaceutical regulatory workflows including:

• 21 CFR Part 11 compliance
• USP <1119> compliance
• EP 2.2.48 / EP 2.2.49 compatibility
• IQ/OQ/PQ qualification support
• GMP-oriented verification processes

Through-Container Measurement

The spectrometer can analyze materials directly through:

• Plastic drum liners
• Glass containers
• Transparent packaging materials

This capability minimizes contamination risk and operator exposure during pharmaceutical inspections.

Integrated PharmaID Library

The system includes a ready-to-use pharmaceutical spectral library containing numerous APIs and excipients for rapid raw material verification.

Applications of Thermo Scientific microPHAZIR RX

Pharmaceutical Raw Material Identification

The analyzer is widely used for incoming raw material verification in pharmaceutical manufacturing environments.

Typical RMID Applications

Active Pharmaceutical Ingredients (APIs)

The instrument verifies pharmaceutical active ingredients rapidly before production begins.

Excipients Verification

Manufacturers can confirm excipient authenticity and composition during warehouse inspection.

Counterfeit Screening

The analyzer helps detect counterfeit or adulterated pharmaceutical materials using spectral fingerprint comparison.

Quality Assurance and Quality Control

The microPHAZIR RX supports QA/QC workflows through fast and repeatable material verification procedures.

Benefits for QA Laboratories

• Faster batch release
• Reduced laboratory workload
• Improved inventory traceability
• Enhanced process safety
• Lower sampling contamination risk

Process Analytical Technology (PAT)

The device can be integrated into at-line PAT workflows for continuous manufacturing support.

PAT Advantages

• Real-time verification
• Reduced process interruption
• Faster troubleshooting
• Improved production efficiency

Chemical and Industrial Material Verification

Beyond pharmaceuticals, the analyzer can also support chemical material identification and industrial process verification applications.

How Near-Infrared (NIR) Spectroscopy Works

Near-Infrared spectroscopy analyzes molecular vibrations generated when NIR light interacts with chemical compounds. The reflected spectral signature is compared against reference libraries to identify materials.

The microPHAZIR RX uses diffuse reflectance NIR technology combined with advanced chemometric processing for rapid identification accuracy.

Advantages of the Thermo Scientific microPHAZIR RX

Faster Inspection Speed

The analyzer reduces inspection time from laboratory hours to seconds directly at the point of need.

Reduced Operational Costs

Portable verification reduces:

• Laboratory testing costs
• Sample transportation
• Production delays
• Material quarantine time

Improved Supply Chain Security

Rapid material authentication minimizes supply chain risk and prevents counterfeit material entry.

Enhanced Operator Safety

Non-contact analysis through containers reduces exposure to hazardous substances.

Rugged Industrial Construction

The splash-proof and dust-resistant housing is suitable for demanding industrial environments.

Thermo Scientific microPHAZIR 1624 RX Specifications

General Specifications

Instrument Type

Handheld Portable Near-Infrared (NIR) Spectrometer

Principle of Operation

Non-destructive chemical analysis using Near-Infrared spectroscopy

Spectral Technology

Diffuse Reflectance NIR Spectroscopy

Spectral Range

1600 – 2400 nm

Spectral Resolution

12 nm at 2000 nm

Measurement Time

Less than 3 seconds to approximately 1 minute depending on application and method configuration.

Sampling Mode

Diffuse reflectance with optional liquid adapters

Light Source

Tungsten light bulb

Display Interface

Integrated color LCD interface with LED indicators

Data Transfer

USB PC synchronization and application transfer

Internal Storage

Integrated onboard memory with PC upload capability

Security Levels

Multiple user-level security access options

Physical Specifications

Weight

2.75 lb / 1.25 kg

Dimensions

19.6 × 11.4 × 6.1 cm

Housing Material

High-strength dust-proof and splash-proof industrial plastic housing

Environmental Protection

Industrial-grade portable enclosure for warehouse and manufacturing use

Battery Specifications

Battery Type

Interchangeable rechargeable lithium-ion battery pack

Operating Time

More than 5 hours continuous operation

Recharge Time

Less than 2 hours

Included Batteries

Two rechargeable battery packs included

Compliance and Validation

Regulatory Standards

• USP Chapter <1119>
• EP 2.2.48 / EP 2.2.49
• 21 CFR Part 11
• JP 15 Supplement 2
• EMEA Compliance
• PIC/S Compliance

Calibration

Factory-calibrated using traceable wavelength and photometric standards with certificate of compliance included.

Package Contents

The standard Thermo Scientific microPHAZIR 1624 RX package commonly includes:

Standard Accessories

Instrument Components

• microPHAZIR 1624 RX analyzer
• USB communication cable
• Two rechargeable batteries
• Battery charger
• Reference holder
• White reference standard (Fluorilon)
• Spare tungsten bulb

Documentation and Software

• Operating manual
• Instrument software
• Calibration certificate
• Warranty documentation

Maintenance Tools

• Allen key
• Phillips screwdriver

Industries Using the microPHAZIR RX

Pharmaceutical Manufacturing

Used for raw material verification and GMP compliance.

Biotechnology Facilities

Supports rapid identification of incoming production materials.

Nutraceutical Production

Ensures ingredient consistency and authenticity.

Chemical Processing

Enables field verification of chemical compounds and materials.

Contract Manufacturing Organizations (CMOs)

Improves material receiving and inspection efficiency.